I. Amakuru Yibanze
Izina rusange: Semaglutide
Ubwoko: GLP-1 reseptor agonist (ikora glucagon-imeze nka peptide-1 igereranya)
Inzira y'Ubuyobozi: Gutera inshinge (rimwe mu cyumweru)
II. Ibyerekana hamwe no kwemerwa murugo
Ibimenyetso Byemejwe
Ubwoko bwa 2 Kuvura Diyabete (Byemejwe na NMPA):
Igipimo: 0.5 mg cyangwa 1.0 mg, rimwe mu cyumweru.
Ibikorwa: Igenga glucose yamaraso kandi igabanya ibyago byumutima.
Umubyibuho ukabije / Kuvura ibiro byinshi
III. Uburyo bwibikorwa ningirakamaro
Uburyo bukuru: Gukora GLP-1 yakira, gutinda gusiba gastric, no kongera guhaga.
Ibyakozwe kuri hypothalamic appetit center, ibuza kurya.
Itezimbere insuline kandi igenga metabolism.
Kugabanya Ibiro (Bishingiye ku bigeragezo mpuzamahanga byo kwa muganga):
Impuzandengo yo kugabanya ibiro mu byumweru 68: 15% -20% (ifatanije nubuzima bwo kubaho).
Abarwayi badafite diyabete (BMI ≥ 30 cyangwa ≥ 27 bafite ibibazo):
Abarwayi ba diyabete: Ingaruka zo kugabanya ibiro bike (hafi 5% -10%).
IV. Bikoreshwa mubaturage no kubirwanya
Umubare w'abaturage
Ibipimo mpuzamahanga (reba OMS):
BMI ≥ 30 (umubyibuho ukabije);
BMI ≥ 27 hamwe na hypertension, diyabete, cyangwa izindi ndwara ziterwa na metabolike (umubyibuho ukabije).
Imyitozo yo murugo: Irasaba gusuzuma abaganga; kuri ubu ikoreshwa cyane cyane mu gucunga ibiro ku barwayi ba diyabete.
Kurwanya
Amateka yumuntu cyangwa umuryango ya medullary tiroyide kanseri (MTC);
Indwara nyinshi ya endocrine neoplasia syndrome y'ubwoko bwa 2 (MEN2);
Abagore batwite cyangwa bonsa;
Indwara zikomeye zo mu gifu (nk'amateka ya pancreatite).
V. Ingaruka z'uruhande n'ingaruka
Ingaruka zisanzwe (incidence> 10%):
Isesemi, kuruka, impiswi, impatwe (kugabanuka ukoresheje igihe kirekire).
Kugabanuka kwifunguro, umunaniro.
Ingaruka zikomeye:
Thyideyide C-selile yibibyimba (ingaruka zerekanwa mubushakashatsi bwinyamaswa, zitarasobanuka mubantu);
Indwara ya pancreatitis, indwara ya gallbladder;
Hypoglycemia (kwitonda bisabwa iyo bikoreshejwe hamwe nibindi bikoresho bya hypoglycemic).
VI. Ikoreshwa rya none mu Bushinwa
Kubona Uburyo:
Kuvura Diyabete: Kwandikirwa mubitaro bisanzwe.
Kuvura ibiro: Bisaba isuzumwa rikomeye na muganga; amashami amwe n'amwe yo mu mashami ya endocrinology arashobora kuyandika.
Ingaruka ziva kumuyoboro utemewe: Ibiyobyabwenge byaguzwe binyuze mumiyoboro itemewe birashobora kuba impimbano cyangwa kubikwa nabi, bikaba byangiza umutekano.
VII. Ibyifuzo byo gukoresha
Kurikiza byimazeyo ibyo Muganga yandikiwe: Koresha nyuma yuko umuganga asuzumye ibipimo bya metabolike n'amateka y'ubuvuzi bw'umuryango.
Kwivanga mubuzima hamwe: Imiti igomba guhuzwa no kugenzura indyo yimyitozo ngororamubiri kugirango igere kubisubizo byiza.
Gukurikirana igihe kirekire: Buri gihe ugenzure imikorere ya tiroyide, imisemburo ya pancreatic, n'umwijima n'impyiko.
Igihe cyo kohereza: Ugushyingo-03-2025