Ibyavuye mu bushakashatsi byagaragaje ko abagabo bahawe inshinge za testosterone zimaze igihe kinini batewe no kuvura nyuma yumwaka 1 kurusha abagabo bahawe inshinge za testosterone nkeya.
Isesengura ryakozwe ku makuru yatanzwe n'abagabo barenga 122.000 muri Amerika ryerekanye ko abagabo bavuwe na testosterone undecanoate (Aveed, Endo Pharmaceuticals) bafite ibipimo nk'ibyo byo kubahiriza mu mezi 6 ya mbere yo kwivuza nk'abagabo bavuwe na testosterone cypionate.Igipimo cyo kubahiriza cyagaragaye kuva ku mezi 7 kugeza 12, aho 8.2% gusa by’abarwayi bavuwe na testosterone cypionate bakomeje kwivuza amezi 12 ugereranije na 41.9% by’abarwayi bavuwe na testosterone idafite ubudahangarwa.
MD, umwungirije wungirije ushinzwe kubaga, Abraham Morgenthaler yagize ati: "Ibimenyetso byerekana ko uburyo bworoshye bwo kuvura testosterone, nk'inshinge zimaze igihe kirekire, ari ingenzi ku bushake bw'abagabo bafite ikibazo cya testosterone yo gukomeza kwivuza".Helio yavuze ko yakoraga mu ishami rya urologiya mu kigo cy’ubuvuzi cya Beth Israel Deaconess ku ishuri ry’ubuvuzi rya Harvard.Yakomeje agira ati: “Hariho abantu benshi bamenya ko ibura rya testosterone ari ubuzima bw'ingenzi kandi ko kuvura testosterone bidashobora guteza imbere ibimenyetso gusa ahubwo binagira ingaruka ku buzima muri rusange nko kunoza isukari mu maraso, kugabanya ibinure ndetse no kwiyongera kw'imitsi, imiterere, amagufwa yuzuye n'impamvu itazwi. .kubura amaraso.Icyakora, izo nyungu zishobora kugerwaho ari uko abagabo bakomeje kwivuza. ”
Morgenthaler na bagenzi be bakoze ubushakashatsi bwimbitse ku makuru yavuye mu bubiko bwa Veradigm, bukubiyemo amakuru y’ubuzima bwa elegitoroniki yavuye mu bigo by’ubuvuzi byo muri Amerika, harimo n’abatangiye gutera inshinge testosterone undecanoate cyangwa testosterone cypionate hagati ya 2014 na 2018. Abagabo bafite imyaka 18 nayirenga.Amakuru yakusanyirijwe mumezi 6 yiyongera guhera muri Nyakanga 2019. Ubuvuzi bwo gufata neza bwasobanuwe nkintera iri hagati yabashinzwe kutarenza inshuro ebyiri zasabwaga gukoreshwa mugihe cyibyumweru 20 kuri testosterone idacanoate cyangwa ibyumweru 4 kuri testosterone cypionate.Gukurikiza imiti byasuzumwe kuva umunsi watewe inshinge ya mbere kugeza umunsi wahagaritswe, guhindura imiti, cyangwa iherezo ryubuvuzi bwa testosterone.Testosterone kutubahiriza mumatsinda ya testosterone idasobanutse yasobanuwe nkikinyuranyo cyiminsi irenga 42 hagati yitariki yo kurangiriraho bwa mbere nitariki yo gutangiriraho bwa kabiri, cyangwa ikinyuranyo cyiminsi irenga 105 hagati yabateganijwe.Kutubahiriza itsinda rya testosterone cypionate byasobanuwe nkintera yiminsi irenga 21 hagati yo kurangiza gahunda imwe no gutangira iyindi.Abashakashatsi basuzumye impinduka z’uburemere bw’umubiri, BMI, umuvuduko wamaraso, urugero rwa testosterone, igipimo cy’indwara nshya zifata umutima, n’impamvu zishobora gutera kuva mu mezi 3 mbere yo guterwa bwa mbere kugeza ku mezi 12 nyuma yo gutangira kwivuza.
Itsinda ry’ubushakashatsi ryari rigizwe nabagabo 948 bafata testosterone undecanoate na 121,852 bafata testosterone cypionate.Ku murongo fatizo, 18.9% by'abagabo bari mu itsinda rya testosterone undecanoate na 41.2% by'abagabo bo mu itsinda rya cypionate ya testosterone ntabwo basuzumye hypogonadism.Hagati ya testosterone yubusa kuri baseline yari hejuru kubarwayi bafata testosterone undecanoate ugereranije nabafata testosterone cypionate (65.2 pg / mL vs 38.8 pg / mL; P <0.001).
Mu mezi 6 yambere, ibipimo byo kubahiriza byari bisa mumatsinda yombi.Mugihe cyamezi 7 kugeza 12, itsinda rya testosterone ridafite ubudahangarwa ryagize igipimo cyinshi cyo gukomera kurenza testosterone cypionate (82% vs 40.8%; P <0.001).Ugereranije n'amezi 12, umubare munini w'abagabo mu itsinda rya testosterone undecanoate bakomeje kuvura naive testosterone (41.9% vs 0.89.9%; P <0.001).Abagabo bafata testosterone cypionate.
Morgenthaler yagize ati: "Igitangaje ni uko 8.2% gusa by'abagabo bateye testosterone cypionate bakomeje kwivuza nyuma y'umwaka 1."Ati: “Agaciro gake cyane k'ubuvuzi bwa testosterone bukoreshwa cyane muri Amerika bivuze ko hakorwa abagabo babuze testosterone.”
Abarwayi bavuwe na testosterone undecanoate bagize impinduka nini cyane muri testosterone yose (171.7 ng / dl vs 59,6 ng / dl; P <0.001) na testosterone yubusa (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).Kwiyongera kwamezi 12 ugereranije nabarwayi bavuwe na testosterone cypionate.Testosterone undecanoate yerekanaga impinduka nke murwego rwa testosterone zose kuruta testosterone cypionate.
Ku mezi 12, bivuze impinduka mubiro, BMI, n'umuvuduko w'amaraso byari bisa hagati yitsinda.Itsinda rya testosterone ridasobanutse ryagize umubare munini wabagabo bafite ikibazo cyo kuvura indwara zidakira ndetse numubyibuho ukabije mugukurikirana, mugihe itsinda rya testosterone cypionate ryagize umubare munini wabagabo basuzumwe na hypertension, kunanirwa k'umutima, n'ububabare budakira.
Morgenthaler avuga ko hakenewe ubushakashatsi bwinshi kugira ngo twumve impamvu abagabo benshi batera testosterone cypionate bahagarika kwivuza mu gihe cy'umwaka umwe.
Ati: “Turashobora gutekereza ko muri ubu bushakashatsi, testosterone undecanoate yakoreshejwe ku kigero kinini cyane mu gihe cy'amezi 12 bitewe no korohereza ibiyobyabwenge bimaze igihe, ariko kugira ngo turebe niba ibyo bishobora guterwa n'izindi mpamvu (nk'igiciro), kwanga inshinge nyinshi zo kwivuza, kutagira iterambere ryinshi mu bimenyetso, cyangwa izindi mpamvu, ”Morgenthaler.
Igihe cyo kohereza: Jul-05-2023